Effect of Clonidine for Suppression of Shivering after General Anesthesia / 대한마취과학회지

We have studied the efficacy of intravenous clonidine to suppress postoperative shivering. Forty healthy patients who received general anesthesia and required treatment for shivering after operation were allocated randomly to two groups. Group 1 received normal saline 5 ml. Group 2 received 75 mcg intravenous clonidine. 2 minutes, 5 minutes and 10 minutes after treatment, the efficacy of treatment was recorded. Five minutes after treatment, 75 mcg clonidine obliterated shivering in 80% of patients. In contrast, none of the patients treated with normal saline had improved. Mean arterial pressure and heart rate were decreased significantly in patients given 75 mcg intravenous clonindine. But, none of them had required treatment for hypotension or bradycardia. We might say that 75 mcg intravenous clonidine is effective to suppress postoperative shivering without significant side effects.

Effect of Doxapram on the Recovery from Vecuronium and Atracurium Neuromuscualr Block / 대한마취과학회지

The purpose of this study is to investigate the effects of doxapram on the rates of spontaneous and neostigmine-induced recovery from neuromuscular block with vecuronium and atracurium. Following intravenous injection of either vecuronium (40 patients) or atracurium (40 patients), recovery index (RI) was measured without administering either doxapram or neostigmine (Group 1), or after administration of a combination of neostigmine 40 ug/kg and doxapram 1 mg/kg (Group 2), neostigmine 40 ug/kg (Group 3) or doxapram 1 mg/kg (Group 4) when twitch tension returned to 25% block of train of four response, each of the four group had 10 patients. The results were such that RI was significantly prolonged after vecuronium in the presence of doxapram compared with Group 1 (13.5 min vs 8.2 min). There was no significant difference in the RI after atracurium in the presence of doxapram compared with Group 1 (7.0 min vs 7.1 min). There was rapid recovery which was significant when neostigmine was administered with or without doxapram (2.4 min vs 2.3 min respectively after vecuronium; 2.3 min vs 2.4 min respectively after atracurium). The authors conclude that administration of doxapram in situation where neuromuscular block with vecuronium is not adequately antagonized does not contribute to rapid recovery from neuromuscular block.